Evolutionary BiologyProtein SciencePeer-reviewed
High-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases
Laura M. Haynes, Matthew L. Holding, Hannah DiGiovanni…·David Ginsburg
This study uses deep mutational scanning to analyze PAI-1's inhibitory interactions with three serine proteases, revealing sequence determinants and evolutionary conservation of specificity.
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