BiochemistrybioRxivPreprint
Allosteric modulation of dimeric GPR3 by ligands in the dimerization interface
Zeming Qiu, Wei Wang, Yingying Nie…·Sanduo Zheng
This study determines cryo-EM structures of GPR3 in active and inactive states, revealing dimerization mechanisms and identifying a negative allosteric modulator targeting the dimerization interface.
DOI 10.1101/2025.04.19.649678