Author

Harlan L. Pietz

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Biophysics· 1

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Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Anat Levit Kaplan· 1 shared Brian K. ShoichetiD· 1 shared Fangyu Liu· 1 shared Ivan S. Kondratov· 1 shared Jesper LevringiD· 1 shared John J. IrwiniD· 1 shared Jue CheniD· 1 shared Jürgen Einsiedel· 1 shared

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2023-2023 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Anat Levit Kaplan

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1 paper

Recent·Most cited

BiophysicsbioRxivSep 9, 2023

Structure-based discovery of CFTR potentiators and inhibitors

Fangyu Liu, Anat Levit Kaplan, Jesper Levring…·Jue Chen

The paper identifies novel CFTR modulators using molecular docking, electrophysiology, cryo-EM, and medicinal chemistry, discovering potentiators and inhibitors with mid-nanomolar activity.

DOI 10.1016/j.cell.2024.04.046

humanelectrophysiology

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