Cell BiologybioRxivPreprint
Activation of PPARγ redirects fibro-adipogenic progenitors to replace ectopic bone with fat in models of fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification
Pratik Koirala, Ziyu Chen, Samerender Nagam Hanumantharao…·Shailesh Agarwal
This study identifies rosiglitazone, a PPARγ agonist, as a potential therapy for fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification by converting ectopic bone to fat.
DOI 10.64898/2026.02.26.708276