Author

Helen H. Yu

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Biochemistry· 1

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

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Annie MoradianiD· 1 shared Justin M. Reitsma· 1 shared Mike J. Sweredoski· 1 shared Raymond J. DeshaiesiD· 1 shared Sonja Hess· 1 shared

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2019-2019 · peak 1/yr

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1 shared paperBiochemistry

Annie MoradianORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintApr 2, 2019

Single subunit degradation of WIZ, a lenalidomide- and pomalidomide dependent substrate of E3 ubiquitin ligase CRL4CRBN

Helen H. Yu, Justin M. Reitsma, Mike J. Sweredoski…·Raymond J. Deshaies

This study identifies WIZ as a novel substrate of the CRL4CRBN E3 ubiquitin ligase complex that is degraded by lenalidomide and pomalidomide, highlighting the mechanism of IMiD-induced protein degradation.

DOI 10.1101/595389

proteomicsexperimental assay

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