Evolutionary BiologybioRxivPreprint
Ancestral resurrection reveals mechanisms of kinase regulatory evolution
Dajun Sang, Sudarshan Pinglay, Sezen Vatansever…·Liam J. Holt
The paper uses ancestral resurrection to show that changes in the β3-C loop and gatekeeper residue in ERK kinases drove the evolution of lower intrinsic autophosphorylation.
DOI 10.1101/331637