Author

Huan Liang

Duke University

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Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:Hi-C· 1

Frequent Co-Authors

Rohit SinghiD· 2 shared Bonnie BergeriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

2 top collaborators · 1 mutual co-author link

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2 shared papersBioinformatics

Rohit SinghORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintAug 6, 2026

COMPASS: Component-Wise Inference of Shared and Gene-Specific Perturbation Response

Huan Liang, Rohit Singh

The paper introduces COMPASS, a model that decomposes genetic perturbation responses into shared and gene-specific components, showing improved accuracy and discrimination compared to existing methods.

DOI 10.64898/2026.08.03.742643

humanCRISPR screen

𝕏 PostBluesky

BioinformaticsCell SystemsPeer-reviewedJul 17, 2026

Foundation model reveals the shared organization of transcription and topologically associating domains

Huan Liang, Bonnie Berger, Rohit Singh

The paper develops a foundation model to analyze TADs and their impact on transcription, finding that TADs enhance co-regulation and this effect declines with aging and changes in cancer cells.

3 citations

humanmouse

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