ImmunologybioRxivPreprint
Inhibition of SHP-1 /2 blocks antigen cross-presentation by human macrophages and dendritic cells
Alexine Simone de Wit, Harry M. Warner, Huang Huang…·Frans Bianchi
This study shows that inhibiting SHP-1/2 reduces antigen cross-presentation by macrophages and dendritic cells, potentially limiting the effectiveness of PD-1 checkpoint therapy.
DOI 10.1101/2025.10.21.683666