Author

Hugo J. van Dooren

Leiden University Medical Center

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Immunology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:statistical model· 1

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Annemarie L Dorjée· 1 shared Betty DiamondiD· 1 shared Cynthia B. AranowiD· 1 shared Jolien SuurmondiD· 1 shared Meggan C. MackayiD· 1 shared René E. M. ToesiD· 1 shared Tom W. J. HuizingaiD· 1 shared Yemil Atisha‐FregosoiD· 1 shared

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1 shared paperImmunology

Annemarie L Dorjée

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1 paper

Recent·Most cited

ImmunologyJournal of AutoimmunityPeer-reviewedMay 25, 2025

IFN-associated B cell hyperactivity is highly enriched in SLE patients harboring Sm/RNP antibodies

Hugo J. van Dooren, Yemil Atisha‐Fregoso, Annemarie L Dorjée…·Jolien Suurmond

The paper identifies a subgroup of SLE patients with high plasmablast frequency and IFN signature, enriched in those with Sm/RNP antibodies, linking IFN to B cell hyperactivity and autoantibody production.

14 citationstop 2%

humanbulk RNA-seq

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