Hui Shen

Single-Atom Modification Enables Reversal of Degradation Selectivity between NSD2 and GSPT1

This study modifies a molecule to create two variants with different target selectivity, showing how small structural changes can control degradation activity.

Gq-pathway activation in hippocampal CA1 astrocytes rescues ischemia-induced memory deficits and synaptic plasticity

This study shows that activating the Gq pathway in hippocampal astrocytes improves memory and synaptic plasticity after stroke in mice.

Survivin inhibition induces PD-L1 expression through cGAS stabilization and attenuates antitumor immunity

This study shows that Survivin inhibition increases PD-L1 expression via cGAS stabilization, leading to immune evasion and reduced antitumor immunity.

An atlas of genetic effects on the monocyte methylome across European and African populations

The paper constructs a multi-ancestry methylome atlas of purified monocytes, identifies population-specific methylation quantitative trait loci, and performs methylome-wide association studies for 41 traits, revealing novel associations for type 2 diabetes.

A stable beneficial symbiotic relationship between endophytic fungus Schizophyllum commune and host plant Panax ginseng

This study identifies an endophytic fungus that enhances ginsenoside content in Panax ginseng by regulating gene expression in the biosynthetic pathway.