Cancer BiologyJournal of Medicinal ChemistryPeer-reviewed
Single-Atom Modification Enables Reversal of Degradation Selectivity between NSD2 and GSPT1
Weizhong Shen, Yihan Liu, Lianchao Liu…·Ke Ding
This study modifies a molecule to create two variants with different target selectivity, showing how small structural changes can control degradation activity.
DOI 10.1021/acs.jmedchem.6c01678