Yihan Liu

This study modifies a molecule to create two variants with different target selectivity, showing how small structural changes can control degradation activity.

This paper identifies a druggable chromatin vulnerability in suppressive neutrophils that can restore antitumor immunity through mSWI/SNF antagonists.

A bifunctional AR–p300/CBP molecule, DALTAC-1, forces a non-native contact between AR and p300 domains, silences AR enhancers and regresses AR-driven prostate tumors in mice while sparing AR-negative lines.

This study identifies S-palmitoylation of OGT and shows it stabilizes OGT by preventing CMA degradation and enhances its interaction with PPP1CC and YAP.

This study uses pan-genomics and deep learning to analyze signal peptides in 287 Bacillus subtilis strains, revealing an open pan-signal peptidome and evolutionary decoupling between signal peptides and mature proteins.

MouseGPT translates raw video of mouse behavior into natural language for automated open-vocabulary analysis, surpassing traditional methods in precision and adaptability.

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.