Xiao Zhang

AlphaVariant uses reinforcement learning with evolutionary priors to optimize enzyme variants from sparse experimental data, achieving high activity improvements in multiple rounds of optimization.

The paper studies genomic signatures of coevolution between a parasitoid fly and its cricket host, revealing arms-race dynamics and selective sweeps driven by host adaptations.

This study examines vegetation and functional composition changes in southwestern China during the late MIS3 to LGM using pollen records, revealing shifts in forest types and functional traits driven by climate change.

This study shows that astrocytes and neurons respond differently to intracortical microstimulation, with astrocytes showing spatially heterogeneous and temporally variable responses.

This study uses a high-resolution palynological record from Erhai Lake to show that Hengduan Mountains vegetation reorganized rapidly in response to climatic oscillations over 35,200 years, with future projections under high-emission scenarios indicating intensified reorganizations.

This study investigates how impaired calcium signaling in precapillary sphincters and pericytes contributes to neurovascular uncoupling after ischemic stroke in mice.

The paper uses machine learning to impute missing mosquito data and improve malaria incidence predictions in Bolivar State, Venezuela, but finds it ineffective for P. falciparum.

The paper constructs a multi-ancestry methylome atlas of purified monocytes, identifies population-specific methylation quantitative trait loci, and performs methylome-wide association studies for 41 traits, revealing novel associations for type 2 diabetes.

ViFIT-assisted histopathology converts diverse H&E-stained images into standardized H&E images and generates virtual fiber images, improving diagnostic workflows across cancer types.

This paper decodes the structural logic of pheromone recognition in silkmoths to design small molecules that disrupt insect mating behavior.

This study investigates the spatial and temporal mismatch between neuronal activity and blood flow responses to intracortical microstimulation in mice, finding that low intensity stimulation preserves neurovascular coupling while high intensity causes mismatched responses and potential ischemia.

The paper develops M2AE, a multi-task multi-view model to impute blood SCFA levels using gut metagenomic data, dietary features, and host characteristics, showing improved performance over existing methods.

This study shows that neurovascular coupling in aged mice is slower and prolonged, with reduced Ca2+ signaling in vascular mural cells, and correlates with decreased spontaneous locomotion.

The paper examines the genomic effects of recent sexual signal loss in crickets, finding pleiotropy, hitchhiking, and regulatory disruption associated with the trait loss.