PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration
Yu Deng, Tatsat Banerjee, Satomi Matsuoka, Debojyoti Biswas, Liz A. Kurtz, Jane A. Borleis, Yu Long, Parijat Banerjee, Huiwang Zhan, Dhiman Sankar Pal, Nathan H. Roy, Masahiro Ueda, Pablo A. Iglesias, Peter N. Devreotes
This study identifies a PIP5K-Ras bistable circuit that drives plasma membrane symmetry breaking, leading to cellular polarity and migration.
Nature Communications · Sep 30, 2026Peer-reviewedCell Biology