Peter N. Devreotes

This study identifies a PIP5K-Ras bistable circuit that drives plasma membrane symmetry breaking, leading to cellular polarity and migration.

The paper introduces Membrane Kymograph Generator, a software tool for automated kymograph generation and analysis of membrane dynamics from live-cell imaging data.

This study uses computational models to investigate how feedback loops in Dictyostelium cells influence polarization, finding that global inhibition is more robust than local inhibition.

This study identifies cytoskeletal feedback loops that regulate Ras/PI3K signaling and cell polarity in Dictyostelium and neutrophils by modulating actin and myosin dynamics.

The paper shows that glycolytic waves in the cell cortex drive migration and cancer progression by providing ATP for morphological events and correlating with metastatic potential.

This study shows that Ras activity has a biphasic effect on cell migration, with both high and low activity impairing movement, and reveals that Ras regulates migration through rapid, non-transcriptional mechanisms.

This paper learns stochastic reaction-diffusion models from limited and noisy data using spatiotemporal features and sparsity enforcement.