Yu Deng

This study identifies a PIP5K-Ras bistable circuit that drives plasma membrane symmetry breaking, leading to cellular polarity and migration.

This study uses computational models to investigate how feedback loops in Dictyostelium cells influence polarization, finding that global inhibition is more robust than local inhibition.

The paper shows that glycolytic waves in the cell cortex drive migration and cancer progression by providing ATP for morphological events and correlating with metastatic potential.

This study shows that Ras activity has a biphasic effect on cell migration, with both high and low activity impairing movement, and reveals that Ras regulates migration through rapid, non-transcriptional mechanisms.