Author

Hung T Nguyen

University at Buffalo, State University of New York

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Biophysics· 1

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Approach:biophysical modeling· 1

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Heyang ZhangiD· 1 shared Lipika BaidyaiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiophysics

Heyang ZhangORCID

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1 paper

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BiophysicsbioRxivPreprintNov 29, 2025

Why PAR is not RNA: ion atmospheres, bridging interactions, and ion-induced structural collapse

Lipika Baidya, Heyang Zhang, Hung T Nguyen

This study develops a coarse-grained model of PAR and uses molecular dynamics to show PAR undergoes stronger structural transitions than RNA in response to divalent ions due to preferential ion binding and bridging.

DOI 10.1101/2025.11.29.691228

biophysical modeling

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