Satchal K. Erramilli

This paper develops a conformation-specific antibody, K27-IgG, to detect K27-linked polyubiquitin and identifies DNAJB1 as a reader and UBE2Q1 as a writer for this ubiquitin chain type.

The paper identifies an unconventional HxD motif in coronaviruses that functions as a coatomer-binding signal, revealing alternative pathways for viral morphogenesis.

This study presents the cryo-EM structure of PLCε, revealing its N-terminal domains and their role in membrane engagement and activity.

This study determines the structure of the human vault cage with PARP4 and NAD+, revealing binding interfaces and NAD+ pockets, and shows proteomics differences in PARP4-depleted vaults.

This study presents cryo-EM structures of AftB from Mycobacterium chubuense, revealing its architecture and mechanism for terminal arabinosylation in mycobacterial cell wall biosynthesis.

This study determines the cryo-EM structures of PimE from Mycobacterium abscessus and elucidates its mechanism of action, providing insights for anti-TB drug development.

This study presents cryo-EM structures of Clostridium perfringens enterotoxin bound to claudin-4, revealing its pore assembly mechanism and potential therapeutic strategies.

This study identifies FLVCR2 as the primary choline transporter at the blood-brain barrier, determines its structures, and elucidates its mechanism of choline uptake.

The paper determines the cryo-EM structure of P. aeruginosa PhuR bound to heme, revealing the role of Y529 in iron coordination and providing insights for developing conformation-specific antibodies.