Hyunbin D. Huh

This study shows that the adherent-to-suspension transition in melanoma cells enhances metastatic potential by reprogramming anchorage dependency, independent of epithelial-to-mesenchymal-like transition pathways.

The paper shows cell competition enables loser cells to gain metastatic potential through anchorage plasticity, mediated by AST factors, and demonstrates this in breast cancer metastasis.