Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End-Joining
Q. Liu, L. Ma, T. Jones, L. Palomero, M. A. Pujana, H. Martinez-Ruiz, P. Ha, J. Murnane, I. Cuartas, J. Seoane, M. Baumann, A. Linge, M. H. Barcellos-Hoff
This study shows HPV-positive HNSCC cells lose TGFβ signaling, shifting DNA repair from homologous recombination to alternative end-joining, increasing PARP inhibitor sensitivity.
bioRxiv · Jun 26, 2018Cancer Biology