T. Jones

Progressive spreading of DNA methylation in the GSTP1 promoter CpG island across transitions from precursors to invasive prostate cancer

The paper examines DNA methylation patterns in the GSTP1 promoter across prostate cancer progression stages and finds increasing methylation from normal to cancerous lesions.

Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate

This paper introduces a chromogenic in situ hybridization method to measure telomere lengths in prostate tissues, aiding in the identification of precancerous lesions.

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

The paper develops a method to spatially quantify mitochondrial DNA copy number in cancer tissues and finds increased mtDNAcn in prostate cancer progression, linked to MYC activity.

Pseudomonas aeruginosa utilises host-derived polyamines to facilitate antimicrobial tolerance

This study shows that Pseudomonas aeruginosa uses host-derived polyamines, like spermidine, to enhance antimicrobial tolerance during infection, despite reduced susceptibility in vitro.

Supraphysiological testosterone induces ferroptosis and activates NF-kappaB mediated immune pathways in prostate cancer through nucleophagy

Segmentation-less, automated vascular vectorization robustly extracts neurovascular network statistics from in vivo two-photon images

This paper introduces a segmentation-less method for automated vascular vectorization from in vivo two-photon images, showing improved robustness to image quality compared to intensity-thresholded methods.

An efficient gene excision system in maize

This paper develops an efficient gene excision system in maize using inducible recombinases to improve transformation and regeneration of fertile plants.

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

The paper identifies potent neutralizing antibodies against SARS-CoV-2 that block receptor binding and protect animals, providing insights for vaccine and therapy development.

Integrated technology platform for accelerated discovery of antiviral antibody therapeutics

This study develops an integrated platform to rapidly discover and validate potent antiviral human monoclonal antibodies against Zika virus.

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

This study isolates and profiles human monoclonal antibodies against SARS-CoV-2 spike protein, identifying neutralizing antibodies targeting the receptor-binding domain.

Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End-Joining

This study shows HPV-positive HNSCC cells lose TGFβ signaling, shifting DNA repair from homologous recombination to alternative end-joining, increasing PARP inhibitor sensitivity.

Complete assembly of a dengue virus type 3 genome from a recent genotype III clade by metagenomic sequencing of serum

This study assembles a complete dengue virus type 3 genome from serum using metagenomic sequencing and identifies co-circulating Japanese encephalitis virus sequences in febrile patients.