Cancer BiologyClinical Cancer ResearchPeer-reviewed
Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End-Joining
Q. Liu, L. Ma, T. Jones…·M. H. Barcellos-Hoff
This study shows HPV-positive HNSCC cells lose TGFβ signaling, shifting DNA repair from homologous recombination to alternative end-joining, increasing PARP inhibitor sensitivity.
DOI 10.1158/1078-0432.ccr-18-1346