Carcinogen induced expansion of atypical B cells and pre-treatment tumor adjacent tertiary lymphoid structures associate with poor response to BCG in non-muscle invasive bladder cancer
P. Yolmo, S. Rahimi, S. Chenard, G. Conseil, D. Jenkins, I. Emon, J. Hamilton, M. Xu, M. Rangachari, E. Michaud, J. Mansure, D. M. Berman, D. R. Siemens, M. Koti
The paper shows that atypical B cells and pre-treatment tumor-associated tertiary lymphoid structures are linked to poor BCG response in NMIBC, with BBN-induced inflammation promoting ABCs in female mice.
bioRxiv · Dec 30, 2022 · PreprintCancer Biology