M. Koti

Fes-deficient macrophages enhance CD8+ T cell priming and tumour control through increased proinflammatory cytokine production and localization

Increased stromal densities of B cells, CD103+ cells, and CD163+ M2-like macrophages associate with poor clinical outcomes in BCG treated non-muscle invasive bladder cancer

This study identifies increased stromal densities of B cells, CD103+ cells, and CD163+ M2-like macrophages as predictors of poor clinical outcomes in BCG-treated NMIBC patients.

Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response

This study investigates the role of the endocannabinoid system in endometriosis pathogenesis and immune response using mouse models and identifies T cell dysfunction and transcriptional changes.

Comparative analysis of syngeneic mouse models of high-grade serous ovarian cancer

The paper compares syngeneic mouse models of high-grade serous ovarian cancer to identify differences in signaling, metabolic, and functional properties, as well as tumor microenvironment variability.

Autophagy mediates cancer cell resistance to doxorubicin induced by the Programmed Death 1/Programmed Death Ligand 1 immune checkpoint axis

This study shows that PD-1/PD-L1 signaling induces autophagy in cancer cells, contributing to drug resistance, and suggests combining PD-1/PD-L1 blockers with autophagy inhibitors could improve chemotherapy effectiveness.

Carcinogen induced expansion of atypical B cells and pre-treatment tumor adjacent tertiary lymphoid structures associate with poor response to BCG in non-muscle invasive bladder cancer

The paper shows that atypical B cells and pre-treatment tumor-associated tertiary lymphoid structures are linked to poor BCG response in NMIBC, with BBN-induced inflammation promoting ABCs in female mice.

PTEN and BRCA1 tumor suppressor loss associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in a murine model of ovarian cancer

This study examines how PTEN and BRCA1 loss in ovarian cancer affects tumor immune microenvironment response to STING pathway activation, showing improved survival in PTEN-deficient tumors with STING therapy.

The influence of age and sex on the pre-treatment immune microenvironment of a carcinogen induced murine model of bladder cancer

This study examines sex and age-related immune differences in healthy and carcinogen-exposed murine bladders using bulk RNA sequencing and spatial immune profiling.

Sexual dimorphism in outcomes of non-muscle invasive bladder cancer: a role of CD163+ M2 macrophages, B cells and PD-L1 immune checkpoint.

This study identifies sexual dimorphism in NMIBC immune microenvironment, showing higher CD163+ macrophages and PD-L1 in female tumors, linked to worse recurrence-free survival.

Gene networks and expression quantitative trait loci associated with platinum-based chemotherapy response in high-grade serous ovarian cancer

The paper identifies gene networks and eQTLs associated with platinum-based chemotherapy response in high-grade serous ovarian cancer using TCGA data.

Chemotherapy induced immunogenic cell death alters response to exogenous activation of STING pathway and PD-L1 immune checkpoint blockade in a syngeneic murine model of ovarian cancer.

This study shows that chemotherapy type affects the response to STING pathway activation and PD-L1 blockade in a murine model of ovarian cancer, with carboplatin + STING + PD-L1 providing the best survival.