M. Xu

Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

The paper identifies neurotrophic signals, particularly FGF9, required for fracture healing by mapping somatosensory afferent circuitry to bone and analyzing gene expression changes in DRG neurons.

Coral hosts actively accumulate inorganic carbon for Symbiodiniaceae to maintain symbiotic relationships

This study shows corals actively accumulate dissolved inorganic carbon for their algal symbionts, supporting symbiosis, and reveals pathways involved in this process.

Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in Candida glabrata

This study investigates the structural and dynamic organization of plasma membrane proteins in Candida glabrata using cryo-ET and live cell imaging, revealing how echinocandin drugs affect their distribution and function.

Driving proteomic imbalance in malignancy provokes proteomic catastrophe and confers tumor suppression

This study shows that loss of HSF1 in MPNST cells causes proteomic imbalance and tumor suppression by inducing proteomic catastrophe through amyloidogenesis and mTORC1 inhibition.

Excessive Dietary Fructose Aggravates Heart Failure via Impairing Myocardial Fatty Acid Oxidation Metabolism in Diet Induced Obese Mouse

This study shows that excessive fructose worsens heart failure in obese mice by impairing fatty acid oxidation and the AMPK-ACC pathway.

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

This study identifies PRMT inhibitors as effective combinational therapies with PARP inhibitors to sensitize HR-proficient ovarian and breast cancer cells to treatment.

Long-term imaging of three-dimensional hyphal development using the ePetri dish

The paper introduces an upgraded ePetri dish system for long-term 3D microbial imaging, demonstrating its ability to monitor hyphal development and detect filter failures.

SUMO Promotes DNA Repair Protein Collaboration to Support Alterative Telomere Lengthening in the Absence of PML

This study shows SUMO promotes DNA repair protein collaboration for telomere maintenance in ALT cancer cells without PML bodies.

Myosin-I Synergizes with Arp2/3 Complex to Enhance Pushing Forces of Branched Actin Networks

This study shows myosin-I enhances the force generation of Arp2/3 complex-nucleated actin networks by thinning them and promoting symmetry breaking.

Neurotensin-Neurotensin Receptor 2 signaling in adipocytes regulates food intake through ceramide metabolism

This study shows that NTS-NTSR2 signaling in white adipocytes regulates food intake by modulating ceramide metabolism and GDF15 production.

Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2

This study identifies BTN3A2 as a primate-specific gene that inhibits SARS-CoV-2 infection by reducing ACE2 expression and blocking viral attachment.

Potent Estrogen Receptor β Agonists with Inhibitory Activity In Vitro, Fail to Suppress Xenografts of Endocrine-Resistant Cyclin-dependent Kinase 4/6 inhibitor-Resistant Breast Cancer Cells

The paper tests the in vivo efficacy of estrogen receptor β agonists combined with tamoxifen in endocrine-resistant breast cancer models, finding no tumor volume reduction despite in vitro success.

Dispersal and evolution of the invasive snail Pomacea canaliculata, an intermediate host of Angiostrongylus cantonensis: A field study around its initial introduction site in China

This study investigates the spatial distribution, phenotypic variation, and dispersal patterns of the invasive snail Pomacea canaliculata in China, revealing human-mediated evolution and potential complexities in parasite transmission.

Structural basis of anticancer drug recognition and amino acid transport by LAT1

This study reports six LAT1 structures bound with ligands, revealing substrate recognition and inhibition mechanisms, including the role of JPH203 as an anticancer drug.

Targeting CD74-positive macrophages improves neoadjuvant therapy in cervical cancer as revealed by single-cell transcriptomics analysis

This study uses single-cell transcriptomics to show that targeting CD74-positive macrophages enhances neoadjuvant therapy efficacy in cervical cancer by altering tumor microenvironment interactions.

CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism

The paper reports cryoEM structures of human CLC-2 chloride channels, revealing a ball-and-chain gating mechanism involving an N-terminal hairpin peptide.

MYCN driven oncogenesis involves cooperation with WDR5 to activate canonical MYC targets and G9a to repress differentiation genes

This study shows MYCN drives oncogenesis by cooperating with WDR5 to activate MYC targets and G9a to repress differentiation genes, and targeting both synergistically inhibits neuroblastoma growth.

Prefrontal Cortex Astroglia Modulate Anhedonia-like Behavior

This study shows that depletion of PFC GFAP+ astroglia induces anhedonia-like behavior, while their activation reverses stress-induced anhedonia, highlighting their role in depression.

An all-atom protein generative model

This paper introduces an all-atom diffusion model for protein structure generation that co-designs structure and sequence, producing high-quality proteins with accurate sidechain behavior.

Reciprocal polarization imaging of complex media.

This paper introduces reciprocal polarization imaging to quantify anisotropic properties of complex media using backscattering Mueller matrices, demonstrating its effectiveness in various applications.

Myocardial IGF2R is a critical mediator of inflammation and fibrosis after ischemia-reperfusion injury

This study investigates the role of IGF2R in myocardial ischemia-reperfusion injury, finding it promotes inflammation and fibrosis and is a potential therapeutic target.

Mitochondrial genome evolution in the Diprionidae: Major gene rearrangement in the basal Hymenoptera

The paper examines mitochondrial gene rearrangements in Diprionidae, showing their potential as phylogenetic markers in Hymenoptera evolution.

Epidemiological evaluation and identification of the insect vector of soybean stay-green associated virus

This study identifies SoSGV as the causative agent of soybean stay-green syndrome and confirms the common brown leafhopper as its vector, revealing its epidemiology and geographical spread.

Spatial transcriptomic atlas of shoot organogenesis in tomato callus

This study creates a spatial transcriptomic atlas of tomato callus during shoot regeneration, identifying cell types and developmental trajectories.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

Carcinogen induced expansion of atypical B cells and pre-treatment tumor adjacent tertiary lymphoid structures associate with poor response to BCG in non-muscle invasive bladder cancer

The paper shows that atypical B cells and pre-treatment tumor-associated tertiary lymphoid structures are linked to poor BCG response in NMIBC, with BBN-induced inflammation promoting ABCs in female mice.

Isolation of strains and their genome sequencing to analyze the mating system of Ophiocordyceps robertsii

The paper isolates Ophiocordyceps robertsii strains and sequences their genomes to study their mating system and genome expansion.

Toxicity of microplastics and plastic additive co-exposure in liver Disse organoids from healthy donors and patient-derived induced pluripotent stem cells

This study uses hiPSC-derived organoids to show that co-exposure to microplastics and TBBPA increases toxicity in patient-derived organoids compared to healthy ones.

Zinc Fingers and Homeoboxes 2 is Required for Diethylnitrosamine-induced Liver Tumor Formation in C57BL/6 Mice

This study shows that Zhx2 acts as an oncogene in a liver tumor model, contradicting previous findings in human cell lines and other models, and correlates with higher ZHX2 expression in HCC patients.

Fat Extract Modulates Calcium Signaling and Protects Against Hyperactive Osteoclastogenesis in Bone Remodeling with Antioxidant Capacity

This study investigates the effects of cell-free fat extract (CEFFE) on osteoclastogenesis, showing its ability to reduce bone loss and inhibit osteoclast formation through antioxidant and calcium signaling modulation.