I. G. Boneca

Leptospiral lipopolysaccharide dampens inflammation through upregulation of autophagy adaptor p62 and NRF2 signaling in macrophages

This study shows that leptospiral LPS activates p62 and NRF2 signaling in macrophages, reducing inflammation and aiding bacterial survival.

Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination

This study identifies microbiota-induced active translocation of peptidoglycan across the intestinal barrier and its preferential access to the brain.

Anti-Leptospira immunoglobulin profiling in mice reveals strain specific IgG and persistent IgM responses associated with virulence and renal colonization

This study profiles Ig responses in mice infected with Leptospira interrogans to assess long-term protection and identifies strain-specific IgG and persistent IgM responses linked to virulence and renal colonization.

A peptide of a type I toxin-antitoxin system induces Helicobacter pylori morphological transformation from spiral-shape to coccoids

This paper identifies a toxin from a type I toxin-antitoxin system in Helicobacter pylori that induces morphological transformation to viable coccoid cells under oxidative stress.

Leptospiral LPS escapes mouse TLR4 internalization and TRIF?associated antimicrobial responses through O antigen and associated lipoproteins

This study shows leptospiral LPS avoids triggering the TRIF-dependent antimicrobial response in mice by not internalizing TLR4, and this evasion depends on O antigen and co-purifying lipoproteins.