Author

C. Werts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 7 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Organism:chicken / avian· 1

Frequent Co-Authors

D. Bonhomme· 4 shared F. Vernel-Pauillac· 4 shared I. G. Boneca· 3 shared B. Adler· 2 shared I. Santecchia· 2 shared M. Fanton d'Andon· 2 shared A. Hajjar· 1 shared A. Ko· 1 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersImmunology

D. Bonhomme

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Inflammation drives age-induced loss of tissue resident macrophages

K. Ade, J. S. Coronilla, D. Obino, T. Weinberger, C. Kaiser, S. Mella, C. Chen, L. Katsimpardi, C. Werts, P. Dardenne, Y. Lallemand, E. Gomez-Perdiguero

The paper shows that inflammation causes age-related loss of tissue-resident macrophages, which cannot be replaced by hematopoietic stem cell-derived cells, and that reducing inflammation prevents this loss and improves liver aging.

bioRxiv · Oct 2, 2022 · PreprintImmunology

Leptospiral lipopolysaccharide dampens inflammation through upregulation of autophagy adaptor p62 and NRF2 signaling in macrophages

D. Bonhomme, I. Santecchia, P. Escoll Guerrero, F. Vernel-Pauillac, I. G. Boneca, C. Werts

This study shows that leptospiral LPS activates p62 and NRF2 signaling in macrophages, reducing inflammation and aiding bacterial survival.

bioRxiv · Aug 24, 2022Immunology

L.interrogans prevents macrophage death and pyroptotic IL1β release through its lipopolysaccharide

D. Bonhomme, V. Hernandez-Trejo, S. Papadopoulos, R. Pigache, M. Fanton d'Andon, A. Outlioua, I. GOMPERTS BONECA, C. Werts

This study shows that Leptospira interrogans prevents macrophage death and pyroptotic IL1β release through its atypical lipopolysaccharide.

bioRxiv · Jul 25, 2022Immunology

Anti-Leptospira immunoglobulin profiling in mice reveals strain specific IgG and persistent IgM responses associated with virulence and renal colonization

F. Vernel-Pauillac, G. L. Murray, B. Adler, I. G. Boneca, C. Werts

This study profiles Ig responses in mice infected with Leptospira interrogans to assess long-term protection and identifies strain-specific IgG and persistent IgM responses linked to virulence and renal colonization.

bioRxiv · Nov 26, 2020Immunology

Role of TLR4 in persistent Leptospira interrogans infection: a comparative in vivo study in mice

N. Nair, M. S. Guedes, A. Hajjar, C. Werts, M. Gomes-Solecki

This study investigates the role of TLR4 in leptospirosis by comparing infection outcomes in humanized TLR4 mice, wild-type mice, and TLR4-deficient mice, finding that human TLR4 does not increase susceptibility to infection.

bioRxiv · Jun 15, 2020 · PreprintMicrobiology

Escape of TLR5 Recognition by Leptospira spp: A Rationale for Atypical Endoflagella

M. Holzapfel, D. Bonhomme, J. Cagliero, F. Vernel-Pauillac, M. Fanton d'Andon, S. Bortolussi, L. Fiette, C. Goarant, E. Wunder, M. Picardeau, A. Ko, D. Werling, M. Matsui, I. Gomberts Boneca, C. Werts

This study investigates TLR5 recognition of Leptospira spp. and finds that their flagellins are highly stable and centrally located, allowing them to evade TLR5 detection.

bioRxiv · May 30, 2020Immunology

Leptospiral LPS escapes mouse TLR4 internalization and TRIF?associated antimicrobial responses through O antigen and associated lipoproteins

D. Bonhomme, I. Santecchia, F. Vernel-Pauillac, M. Caroff, P. Germon, G. Murray, B. Adler, I. G. Boneca, C. Werts

This study shows leptospiral LPS avoids triggering the TRIF-dependent antimicrobial response in mice by not internalizing TLR4, and this evasion depends on O antigen and co-purifying lipoproteins.

bioRxiv · May 18, 2020Immunology