Leptospiral LPS escapes mouse TLR4 internalization and TRIF?associated antimicrobial responses through O antigen and associated lipoproteins
D. Bonhomme, I. Santecchia, F. Vernel-Pauillac, M. Caroff, P. Germon, G. Murray, B. Adler, I. G. Boneca, C. Werts
This study shows leptospiral LPS avoids triggering the TRIF-dependent antimicrobial response in mice by not internalizing TLR4, and this evasion depends on O antigen and co-purifying lipoproteins.
bioRxiv · May 18, 2020Immunology