Author

E. S. Andersen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Bioengineering· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:cryo-EM· 3 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. K. S. McRae· 4 shared C. Geary· 2 shared A. Boussebayle· 1 shared A. C. Brown· 1 shared A. Chenchar· 1 shared A. Krissanaprasit· 1 shared B. K. Hansen· 1 shared B. K. Pedersen· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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4 shared papersBiochemistry

E. K. S. McRae

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Tertiary structure of single-instant RNA molecule reveals folding landscape

J. Liu, E. K. S. McRae, C. Geary, E. S. Andersen, G. Ren

The paper uses cryo-electron tomography to study the folding landscape of an RNA origami 6-helix bundle, revealing multiple conformations and a possible folding pathway.

bioRxiv · May 19, 2023 · PreprintBiochemistry

An RNA origami robot that traps and releases a fluorescent aptamer

N. Sampedro Vallina, E. K. S. McRae, C. Geary, E. S. Andersen

This paper introduces an RNA origami robot called Traptamer that senses RNA strands, acts as a Boolean AND gate, and releases a fluorescent aptamer through mechanical reconfiguration.

bioRxiv · May 19, 2023 · PreprintBioengineering

RNA origami scaffolds as a cryo-EM tool for investigating aptamer-ligand binding of a Broccoli-Pepper FRET pair

N. S. Vallina, E. K. S. McRae, B. K. Hansen, A. Boussebayle, E. S. Andersen

This study uses RNA origami scaffolds to enhance cryo-EM resolution of small aptamer-ligand complexes, revealing precise conformational changes in a Broccoli-Pepper FRET pair.

bioRxiv · Aug 25, 2022 · PreprintBiochemistry

Cryo-EM structure and functional landscape of an RNA polymerase ribozyme

E. K. S. McRae, C. J. K. Wan, E. L. Kristoffersen, K. Hansen, E. Gianni, I. Gallego, J. F. Curran, J. Attwater, P. Holliger, E. S. Andersen

The paper determines the cryo-EM structure of a triplet polymerase ribozyme and maps its functional landscape using mutation analysis.

bioRxiv · Aug 23, 2022Biochemistry

Enhanced Anticoagulation Activity of Functional RNA Origami

A. Krissanaprasit, C. M. Key, K. Froehlich, S. Pontula, E. Mihalko, D. M. Dupont, E. S. Andersen, J. Kjems, A. C. Brown, T. H. LaBean

This paper develops RNA origami displaying RNA aptamers as anticoagulants, showing enhanced thrombin inhibition and reversible activity with potential for clinical use.

bioRxiv · Sep 29, 2020 · PreprintBioengineering

Thermogenic genes are blunted whereas brown adipose tissue identity is preserved in human obesity

N. Z. Jespersen, M. W. Andersen, V. H. Jensen, T. W. Staerker, M. C. Severinsen, L. Peijs, R. Soares, I. Forss, E. S. Andersen, C. H. Hahn, P. Homee, S. Mandrup, B. K. Pedersen, S. Nielsen, C. Scheele

The paper identifies a reduction in thermogenic genes but preserved brown adipose tissue identity in human obesity through transcriptomic analysis of BAT and WAT.

bioRxiv · May 7, 2020 · PreprintCell Biology

FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest

S. Soeberg, E. S. Andersen, N. B. Dalgaard, I. Jarlhelt, N. L. Hansen, N. Hoffmann, T. Vilsboell, A. Chenchar, M. Jensen, T. J. Grevengoed, S. A. J. Trammell, F. K. Knop, M. P. Gillum

This study shows that alcohol increases FGF21 levels in humans and that FGF21 reduces alcohol intake in mice.

bioRxiv · Feb 13, 2018Physiology