Bile Acid pool composition and Gallbladder function are controlled by TGR5 to protect the liver against Bile Acid overload
V. BIDAULT-JOURDAINNE, G. MERLEN, M. GLENISSON, I. DOIGNON, I. GARCIN, N. PEAN, R. BOISGARD, J. URSIC-BEDOYA, M. SERINO, C. ULLMER, L. HUMBERT, A. ABDELRAFEE, E. VIBERT, J.-C. DUCLOS-VALLEE, D. RAINTEAU, T. TORDJMANN
This study shows that TGR5 regulates bile acid pool composition and gallbladder function to protect the liver from bile acid overload in mice and humans.
bioRxiv · Feb 18, 2020 · PreprintPhysiology