Hyaluronan Synthesis Inhibition Impairs Antigen Presentation and Delays Transplantation Rejection
P. L. Marshall, N. Nagy, G. Kaber, G. L. Barlow, A. Ramesh, B. J. Xie, M. H. Linde, N. L. Haddock, C. A. Lester, Q.-L. Tran, C. R. de Vries, A. Malkovskiy, I. Gurevich, H. Martinez, H. F. Kuipers, , P. L. Bollyky
This study shows that inhibiting hyaluronan synthesis with 4MU impairs antigen presentation and delays transplant rejection in mice and human T-cell reactions.
bioRxiv · Aug 28, 2020Immunology