Cryo-EM analyses of wild-type and oncogenic KIT mutants reveal structural oncogenic plasticity and a novel Achilles heel for therapeutic intervention
S. G. Krimmer, N. Bertoletti, Y. Suzuki, L. Katic, J. Mohanty, S. Shu, S. Lee, I. Lax, W. Mi, J. Schlessinger
This study uses cryo-EM to analyze wild-type and oncogenic KIT mutants, revealing structural changes and a potential therapeutic target in cancer.
bioRxiv · Sep 8, 2022 · PreprintBiochemistry