S. Shu

Nanobodies against SARS-CoV-2 non-structural protein Nsp9 inhibit viral replication by targeting innate immunity

This paper designs nanobodies against SARS-CoV-2 Nsp9 to inhibit viral replication, showing effectiveness against multiple variants in HEK293-ACE2 cells.

The first two chromosome-scale genome assemblies of American hazelnut enable comparative genomic analysis of the genus Corylus

This paper presents the first chromosome-scale genome assemblies of American hazelnut, enabling structural variation analysis and phylogenetic studies of self-incompatibility in the Corylus genus.

JGI Plant Gene Atlas: An updateable transcriptome resource to improve structural annotations and functional gene descriptions across the plant kingdom

The paper introduces the JGI Plant Gene Atlas, a resource that improves gene function annotations by analyzing transcript abundance across 18 species and 604 tissues, identifying 64,620 genes with unknown functions.

Cryo-EM analyses of wild-type and oncogenic KIT mutants reveal structural oncogenic plasticity and a novel Achilles heel for therapeutic intervention

This study uses cryo-EM to analyze wild-type and oncogenic KIT mutants, revealing structural changes and a potential therapeutic target in cancer.

A spatial map of human macrophage niches links tissue location with function

The paper identifies distinct macrophage niches in human breast and colon tissues using single-cell RNA sequencing and imaging, linking their spatial distribution to functional roles.

Multiplex knockout of trichome-regulating MYB duplicates in hybrid poplar using a single gRNA

A single gRNA targeting conserved sequences enabled efficient mutagenesis of a multigene family, resulting in trichomeless and triterpene-free poplar mutants.

The genome of stress tolerant crop wild relativePaspalum vaginatum leads to increased biomassproductivity in the crop Zea mays

This study sequenced Paspalum vaginatum, a stress-tolerant wild relative of maize, and found that inducing trehalose accumulation in maize increases biomass through autophagy.

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

H2O2/ABA signal pathway participates in the regulation of stomata opening of cucumber leaves under salt stress by putrescine

This study shows that exogenous putrescine alleviates salt stress-induced photosynthesis inhibition in cucumber by regulating stomatal aperture through the H2O2/ABA signaling pathway.

The Ceratodon purpureus genome uncovers structurally complex, gene rich sex chromosomes

The paper compares genomes of male and female mosses to study sex chromosome evolution, finding gene-rich, non-degenerated UV sex chromosomes.

Hybridization history and repetitive element content in the genome of a homoploid hybrid, Yucca gloriosa (Asparagaceae)

This study investigates the hybridization history and transposon dynamics in Yucca gloriosa, a homoploid hybrid, using whole genome resequencing and mRNA-seq.

The Aquilegia genome: adaptive radiation and an extraordinarily polymorphic chromosome with a unique history

The paper presents the genome of Aquilegia coerulea and shows extensive allele sharing and introgression among species, with a unique chromosome evolutionary history.

Exogenous putrescine alleviates photoinhibition caused by salt stress through increasing cyclic electron flow in cucumber

This study shows exogenous putrescine increases cyclic electron flow in cucumber under salt stress, improving ATP/NADPH ratios and reducing photoinhibition.

The Sorghum bicolor reference genome: improved assembly and annotations, a transcriptome atlas, and signatures of genome organization

This paper improves the Sorghum bicolor reference genome, annotates it, and constructs a transcriptome atlas, revealing genomic features and gene expression patterns across developmental stages.