Hyper-Truncated Glycans Augment the Activity of Neutrophil Granule Myeloperoxidase
H. C. Tjondro, J. Ugonotti, R. Kawahara, S. Chatterjee, I. Loke, S. Chen, F. Soltermann, H. Hinneburg, B. L. Parker, V. Venkatakrishnan, R. Dieckmann, O. C. Grant, J. Bylund, A. Rodger, R. J. Woods, , M. Thaysen-Andersen
This study identifies hyper-truncated glycans on neutrophil myeloperoxidase (MPO) that enhance enzyme activity and inhibition potential, revealing their functional role in immune responses.
bioRxiv · Jul 24, 2020 · PreprintBiochemistry