R. J. Woods

This study shows ion exchange biomaterials can capture daptomycin in the gut, preventing resistance evolution in off-target bacteria.

This study tracks genetic and phenotypic changes in antibiotic resistance in a single patient's infection over time, revealing no pan-resistant isolate and complex patterns of collateral sensitivity and combination therapy responses.

The paper estimates the within-host effective population size and mutation rate of influenza A virus in acute infections using sequence data from 200 patients.

This study identifies hyper-truncated glycans on neutrophil myeloperoxidase (MPO) that enhance enzyme activity and inhibition potential, revealing their functional role in immune responses.

This study investigates PD-L1 glycosylation patterns and their impact on interactions with PD-1 and clinical antibodies, revealing site-specific glycan structures and potential functional implications.

The paper characterizes glycosylation of SARS-CoV-2 Spike and ACE2 using glycomics and simulations to understand their interactions and guide immunogen design.

This study shows that cholestyramine, when used with daptomycin, reduces the spread of antibiotic-resistant Enterococcus faecium in mice.

This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.

The paper analyzes SARS-CoV-2 spike protein glycan structures and their impact on immune recognition, finding that glycans extensively shield the protein surface from antibodies.

This study investigates how the CI-MPR receptor binds and releases carbohydrates through allosteric domain cooperativity using biophysical methods and crystal structures.

This study identifies Gat1, a glycogenin homolog, as essential for adding the terminal sugar to Skp1 in Toxoplasma gondii, which is critical for parasite growth.

This study shows that maintaining large populations of drug-sensitive bacteria can delay the rise of drug-resistant bacteria using containment strategies.

This study shows that RNA viruses evolve high mutation rates as a byproduct of selection for faster replication, not because of adaptive advantages.

This study uses viral sequence data from a community-based cohort to estimate within-host population dynamics and transmission bottlenecks of influenza A virus, finding that stochastic processes dominate its evolution.

This paper introduces HR-HRPF to measure solvent accessible surface area and evaluates its ability to distinguish accurate molecular models.