B. L. Parker

Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues

The paper identifies inter-individual transcriptional correlations across metabolic tissues to infer signaling mechanisms, validating findings with known biological roles.

Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis

This study characterizes the skeletal muscle arginine methylome in health and disease, revealing significant remodeling in ALS and identifying potential therapeutic targets.

Affinity purification-mass spectrometry and single fiber physiology/proteomics reveals mechanistic insights of C18ORF25

The paper identifies C18ORF25 interactors and characterizes its role in skeletal muscle physiology using mass spectrometry and single fiber proteomics.

Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

This study identifies resistance mechanisms to TEAD inhibitors by showing MAPK hyperactivation can counteract their effects and suggests combining TEAD and MEK inhibition as a therapeutic strategy.

Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle.

This study identifies ALPK3's role in maintaining sarcomere integrity and proteostasis in striated muscle by localizing to the M-band and interacting with SQSTM1.

Interrogating Metabolic Interactions Between Skeletal Muscle and Liver Circadian Clocks In Vivo

The paper investigates the role of circadian clocks in liver and skeletal muscle in glucose metabolism, finding that inter-organ communication is necessary for systemic glucose homeostasis.

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

This study identifies TRARG1 as a GSK3 substrate that regulates GLUT4 trafficking and insulin sensitivity through phosphorylation events.

Hyper-Truncated Glycans Augment the Activity of Neutrophil Granule Myeloperoxidase

This study identifies hyper-truncated glycans on neutrophil myeloperoxidase (MPO) that enhance enzyme activity and inhibition potential, revealing their functional role in immune responses.

Integrated glycoproteomics identifies a role of N-glycosylation and galectin-1 on myogenesis and muscle development

The paper identifies N-glycosylation and galectin-1 as key regulators of myogenesis and muscle development through integrated glycoproteomics and functional studies.

The Nucleosome Remodeling and Deacetylase complex has an asymmetric, dynamic, and modular architecture

This study reveals the asymmetric and dynamic architecture of the NuRD complex using integrated biochemical and structural methods.

Mechanism of preferential complex formation by Apoptosis Signal-regulating Kinases

This study identifies the mechanism by which ASK1-3 kinases form preferential heterocomplexes through their SAM domains, revealing structural insights into their role in inflammatory signaling.