Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool
R. K. Wang, C. Ascanelli, A. M. Abdelbaki, A. Y. Fung, T. Rasmusson, I. Michaelides, K. Roberts, C. Lindon
This study characterizes a PROTAC-based degrader of AURKA, showing differential targeting of subcellular AURKA pools and distinct phenotypic effects compared to traditional inhibitors.
bioRxiv · Jul 22, 2020Cell Biology