K. Roberts

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

This study integrates single-cell and spatial transcriptomics with histopathology to identify cellular and molecular changes in lung alveolar damage during COVID-19 progression.

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

The paper traces the origin of four synchronous renal tumours in a child to an early embryonic MTOR mutation, showing its role in tumour development and clinical implications.

Preserving endothelial integrity in human saphenous veins during preparation for coronary bypass surgery

This study compares heparinized saline and blood solutions for preserving saphenous vein endothelium during coronary bypass graft preparation, finding blood better preserves endothelial integrity and reduces oxidative stress.

Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma

The paper uses spatial transcriptomics and scRNA-Seq to analyze fibroblast subtypes in pancreatic ductal adenocarcinoma, linking their transcriptomes to clinical outcomes and suggesting therapeutic targets.

Characterizing the polarization continuum of macrophage subtypes M1, M2a and M2c

This study characterizes four macrophage subtypes using proteomics and functional assays, showing M2c macrophages upregulate pro-inflammatory markers and dexamethasone induces partial repolarization from M1 to M2c.

A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens

This paper introduces a suspension culture technique for cancer organoids that improves expansion efficiency and enables large-scale perturbation screens.

Cells of the human intestinal tract mapped across space and time

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool

This study characterizes a PROTAC-based degrader of AURKA, showing differential targeting of subcellular AURKA pools and distinct phenotypic effects compared to traditional inhibitors.

Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

The paper compares tumor and normal single-cell mRNA data to show neuroblastoma cells resemble fetal sympathoblasts across diverse samples.

Heme-Sensing Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

The paper identifies the heme-sensing pathway as a regulator of MCL-1 expression in B-lineage acute leukemia, showing that modulating this pathway enhances sensitivity to BH3-mimetics.

Cellular mRNA signals in human kidney tumors

This study analyzes mRNA signals in 1,300 kidney tumors to determine their differentiation state and origin, finding that childhood tumors show fetal signals while most adult tumors do not, with exceptions in certain cancer types.

Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohns disease

The paper maps the developing human gut at 6-10 weeks post-conception using single-cell sequencing and links fetal transcriptional patterns to childhood Crohn's disease.

The genomic basis of evolved virus resistance is dependent on environmental resources

This study identifies genomic mechanisms of virus resistance in a lepidopteran pest, showing that resistance evolves differently under varying nutritional conditions and is linked to metabolic, immune, or cytoskeleton pathways.

Protection of rhesus macaques against vaginal SHIV challenges by VRC01 and an anti-α4β7 antibody

This study shows that combining VRC01 and Rh-4β7 antibodies delays SHIV infection, preserves CD4+ T cells, and alters immune responses in macaques.

Changes in temperature alter susceptibility to a virus following a host shift

The paper investigates how temperature affects viral susceptibility across 45 Drosophilidae species, finding that temperature increases variance in susceptibility but not mean viral load.

Analysis of Bone Healing with a Novel Bone Wax Substitute Compared to Bone Wax in a Porcine Bone Defect Model

This study compares a novel bone wax substitute (OsteoStat) with traditional bone wax in a porcine bone defect model, finding greater new bone formation with OsteoStat.