Fatty liver-mediated glycine restriction impairs glutathione synthesis and causes hypersensitization to acetaminophen
A. Ghrayeb, B. Agranovich, D. Peled, A. C. Finney, I. Abramovitch, J. Fernandez Garcia, J. G. Traylor, S. Drucker, S. I. Fernandes, N. Weissman, Y. E. Chen, O. Rom, I. Mor, E. Gottlieb
This study shows fatty liver reduces glycine, impairing glutathione synthesis and increasing sensitivity to acetaminophen toxicity in mice.
bioRxiv · Jan 16, 2023 · PreprintBiochemistry