Y. E. Chen

Discovery and engineering of the antibody response against a prominent skin commensal

The paper identifies an antibody response against Staphylococcus epidermidis and shows how it can be engineered for therapeutic vaccination.

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

Fatty liver-mediated glycine restriction impairs glutathione synthesis and causes hypersensitization to acetaminophen

This study shows fatty liver reduces glycine, impairing glutathione synthesis and increasing sensitivity to acetaminophen toxicity in mice.

IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbits

This study shows that IDOL deficiency reduces atherosclerosis in rabbits fed a high-cholesterol diet by improving lipid metabolism and bile acid excretion.

Eliciting a potent antitumor immune response by expressing tumor antigens in a skin commensal

This paper shows that expressing tumor antigens in skin commensal bacteria can elicit a potent antitumor immune response without causing autoimmunity.

Decoding commensal-host communication through genetic engineering of Staphylococcus epidermidis

This study identifies bacterial molecules in S. epidermidis that induce specific immune responses through combinatorial signaling with host receptors, revealing distinct immune signaling pathways for commensal and pathogenic behaviors.