Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β cell survival and function
M. Hu, I. Kim, I. Moran, W. Peng, O. Sun, A. Bonnefond, A. Khamnis, S. Bonas-Guarch, P. Froguel, G. A. Rutter
The paper identifies multiple genetic variants at the SLC30A8 locus that influence enhancer activity and β cell function, with some variants affecting gene expression and insulin secretion.
bioRxiv · Jul 13, 2023 · PreprintCell Biology