Author

A. Bonnefond

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

P. Froguel· 4 shared C. Bourouh· 2 shared C. Carney· 2 shared E. Courty· 2 shared F. Oger· 2 shared F. Pattou· 2 shared G. A. Rutter· 2 shared J. Kerr-Conte· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCell Biology

P. Froguel

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Author profile →

4 papers

Recent·Most cited

Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β cell survival and function

M. Hu, I. Kim, I. Moran, W. Peng, O. Sun, A. Bonnefond, A. Khamnis, S. Bonas-Guarch, P. Froguel, G. A. Rutter

The paper identifies multiple genetic variants at the SLC30A8 locus that influence enhancer activity and β cell function, with some variants affecting gene expression and insulin secretion.

bioRxiv · Jul 13, 2023 · PreprintCell Biology

Control of human pancreatic beta cell kinome by GLP-1R biased agonism

J. Xiao, L. Eleid, T. Buenaventura, R. Boutry, A. Bonnefond, B. Jones, G. A. Rutter, P. Froguel, A. Tomas

This study compares kinase activity profiles in human pancreatic beta cells stimulated by GLP-1R agonists with different bias, revealing distinct kinomic responses and potential therapeutic targets.

bioRxiv · Feb 25, 2023Cell Biology

A crosstalk between E2F1 and GLP-1 signaling pathways modulates insulin secretion

C. Bourouh, E. Courty, G. Pasquetti, X. Gromada, N. Rabhi, C. Carney, M. Moreno, R. Boutry, L. Rolland, E. Caron, Z. Benfodda, P. Meffre, J. Kerr-Conte, F. Pattou, P. Froguel, , J.-S. Annicotte

This study shows that E2F1 and GLP-1 signaling pathways interact to regulate insulin secretion and glucose homeostasis in beta cells.

bioRxiv · Apr 16, 2021Physiology

Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs

F. Oger, C. Bourouh, X. Gromada, M. Moreno, C. Carney, E. Courty, N. Rabhi, E. Durand, S. Amanzougarene, L. Berberian, M. Derhourhi, L. Rolland, S. A. Hannou, P.-D. Denechaud, Z. Benfodda, , J.-S. ANNICOTTE

bioRxiv · Oct 14, 2020Physiology