M. Hu

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models

This study uses a protein language model to discover new phosphorus-cycling protein families in deep-sea cold seep sediments, revealing novel microbial processes and ecological roles.

Australian researchers' perceptions and experiences with stem cell registration.

This study examines Australian researchers' perceptions of stem cell registration, finding that registration is seen as a publication hurdle and often incomplete, undermining registry goals.

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

This study identifies low tumorous magnesium content as a driver factor of colorectal cancer by showing its impact on gene mutations, EMT activation, and cell migration through DBN1 phosphorylation.

VHL loss enables immune checkpoint blockade therapy by boosting type I interferon response.

This study shows that VHL loss in ccRCC enhances anti-PD-1 therapy efficacy by increasing type I interferon response through HIF1/HIF2-mediated mtDNA leakage.

Enterocytozoon hepatopenaei Proliferate in Procambarus clarkii: A Warning for Crayfish and Shrimp Aquaculture

This study shows that crayfish (Procambarus clarkii) can harbor and transmit the microsporidian parasite Enterocytozoon hepatopenaei, posing a risk to shrimp farming.

Addressing preferred orientation in single-particle cryo-EM through AI-generated auxiliary particles.

This paper introduces cryoPROS, an AI method to address preferred orientation in cryo-EM, improving resolution without special experimental techniques.

Electrostatic modulation of signaling at cell membrane: Waveform- and time-dependent electric control of ERK dynamics

This study shows that alternating current electric fields can modulate ERK signaling in epithelial cells through waveform- and timing-dependent electrostatic interactions.

Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β cell survival and function

The paper identifies multiple genetic variants at the SLC30A8 locus that influence enhancer activity and β cell function, with some variants affecting gene expression and insulin secretion.

Structure-Activity Relationship Study Identifies a Novel Lipophilic Amiloride Derivative that Efficiently Kills Chemoresistant Breast Cancer Cells

This study identifies a novel amiloride derivative, LLC1, that shows potent cytotoxicity against chemoresistant breast cancer cell lines but limited efficacy in a metastatic mouse model.

Endothelial cell-derived lactate triggers mesenchymal stem cell histone lactylation to attenuate osteoporosis

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

Targeting GDF15 as a potential therapy for low back pain originating from endplate

This study shows that GDF15 promotes osteoclast fusion and angiogenesis in endplate instability, and inhibiting GDF15 alleviates low back pain.

Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2

This study identifies potent pan-sarbecovirus neutralizing antibodies from vaccinated macaques, showing broad neutralization against SARS-CoV-2 variants and related viruses.

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

This paper describes a ferritin-based nanoparticle vaccine, DCFHP-alum, that induces strong, long-lasting neutralizing antibodies against SARS-CoV-2 variants in non-human primates.

Mechanistic dissection of alga recognition and uptake in coral-algal endosymbiosis

The paper identifies LePin as a key lectin in coral-algal recognition and uses RNAi and scRNA-seq to uncover gene programs and receptors involved in algal uptake and symbiosome formation.

Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

This study shows that reducing Mrpl54 expression in mice decreases mitochondrial-encoded protein content but does not improve metabolic health or lifespan.

Effect and mechanism of black soybean peptides alleviating oxidative damage in the celiac disease cell model

This study investigates how black soybean peptides alleviate oxidative damage caused by alpha gliadin peptide in a celiac disease cell model.

Nanotopography modulates intracellular excitable systems through cytoskeleton actuation

The paper shows nanotopography is sensed directly by cytoskeletal networks, with implications for texture sensing and guidance cues in microenvironments.

Ratiometric NAD+ sensors reveal subcellular NAD+ modulators

The paper introduces NAD+ sensors to measure subcellular and clinical NAD+ dynamics, revealing NAD+ redistribution effects of -GPC in live cells.

Mouse primary T cell phosphotyrosine proteomics enabled by BOOST

The paper applies the BOOST method to perform phosphotyrosine proteomics on mouse primary T cells, demonstrating improved quantitation depth and accuracy by disabling the ΦSDM parameter in Orbitrap instruments.

Identification of two bZIP transcription factors that regulate development of pavement and trichome cells in Arabidopsis thaliana by single-cell RNA-sequencing

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

ECD of PepT1 interacts with TM1 to facilitate substrate transport

The paper reports the structure of PepT1 from horse, showing the extracellular domain (ECD) interacts with TM1 and bridges N- and C-domains, with ECD deletion or mutations impairing transport activity.

Reconstructing mutational lineages in breast cancer by multi-patient-targeted single cell DNA sequencing

This study develops a multi-patient-targeted scDNA-seq method to profile informative mutations in breast cancer and identifies mutational lineages across multiple tumors.

Global Mutational Sweep of SARS-CoV-2: from Chaos to Order

The paper analyzes SARS-CoV-2 genome sequences to show mutation sweeps driven by emerging variants, which may prolong the pandemic and challenge control efforts.

Non-coding function for mRNAs in Focal Adhesion Architecture and Mechanotransduction

The paper identifies non-coding mRNAs localized to focal adhesions, showing they function as scaffolds to maintain FA structure and function through RNA binding protein G3BP1.

Durability of immune responses to the BNT162b2 mRNA vaccine

This study shows that antibody and T cell responses to the BNT162b2 vaccine wane significantly at 6 months, suggesting a potential need for a third booster dose.

Swine H1N1 influenza virus variants with enhanced polymerase activity and HA stability promote airborne transmission in ferrets

Ultrafast, one-step, and microwave heating-based synthesis of DNA/RNA-AuNP conjugates

This paper develops a microwave heating-based method to rapidly synthesize DNA/RNA-AuNP conjugates with high stability and broad applicability.