Targeting YAP mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology
H. Li, M. Kuhn, R. A. Kelly, A. Singh, K. K. Palanivel, I. Salama, M. L. De Ieso, W. D. Stamer, P. S. Ganapathy, S. Herberg
This study investigates how ECM stiffening affects YAP mechanosignaling in SC cells and shows that disrupting YAP signaling improves outflow facility in glaucoma.
bioRxiv · Sep 8, 2023 · PreprintCell Biology