S. Herberg

Targeting YAP mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology

This study investigates how ECM stiffening affects YAP mechanosignaling in SC cells and shows that disrupting YAP signaling improves outflow facility in glaucoma.

YAP/TAZ inactivation with simvastatin attenuates glucocorticoid-induced human trabecular meshwork cell dysfunction

This study shows that simvastatin reduces YAP/TAZ activity and ECM dysfunction in glucocorticoid-treated human trabecular meshwork cells.

YAP/TAZ mediate TGFβ2-induced Schlemm's canal cell dysfunction

This study shows that YAP/TAZ signaling is involved in TGFβ2-induced dysfunction of Schlemm's canal cells and that inhibiting YAP/TAZ can reduce this dysfunction.

Effects of netarsudil-family Rho kinase inhibitors on human trabecular meshwork cell contractility and actin remodeling using a bioengineered ECM hydrogel

Engineering a 3D hydrogel system to study optic nerve head astrocyte morphology and behavior in response to glaucomatous insult

This study develops a 3D hydrogel system to mimic the in vivo mouse optic nerve head astrocyte microenvironment and assesses their reactivity to TGFβ2 treatment.

Extracellular matrix stiffness and TGFβ2 regulate YAP/TAZ activity in human trabecular meshwork cells

This study shows that ECM stiffness and TGFβ2 regulate YAP/TAZ activity in HTM cells, contributing to glaucoma progression.

Engineering a thixotropic and biochemically tunable hyaluronan and collagen bioink for biofabrication of multiple tissue construct types

This paper develops a tunable bioink using collagen and hyaluronan with thixotropic properties and modular ECM components to support multiple tissue types in 3D bioprinting.

Mechanosensitive channel inhibition attenuates TGFβ2-induced actin cytoskeletal remodeling and reactivity in mouse optic nerve head astrocytes.

This study shows that inhibiting mechanosensitive channels reduces TGFβ2-induced actin remodeling and reactivity in optic nerve head astrocytes.

A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling

This paper develops a biomimetic HTM hydrogel model to study glaucoma pathology and test therapeutic interventions.

Simulating the human tumor microenvironment in colorectal cancer organoids in vitro and in vivo

This study creates human colorectal cancer organoids with stromal ECM layers, showing they maintain ECM architecture in vivo and induce epithelial or mesenchymal phenotypes based on TME order.

Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration

This study shows that scaffold-free human mesenchymal stem cell tubes, with specific geometry and morphogen presentation, enhance endochondral bone regeneration in critical-sized femoral defects compared to loose hMSC sheets.

Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair

The paper demonstrates that engineered human mesenchymal stem cell condensations with dual BMP-2 and TGF-β1 promote functional healing of critical-sized femoral defects via endochondral ossification, with healing rate and extent dependent on in vivo mechanical environment.

Recapitulating bone development for tissue regeneration through engineered mesenchymal condensations and mechanical cues

This study shows that mechanical loading enhances bone regeneration through engineered mesenchymal condensations, mimicking endochondral ossification without heterotopic bone formation.