Author

Ian Brown

Buck Institute for Research on AgingPrimary ORCID profile (0000-0001-6329-2547 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Ian BrowniD2 papers · Envoi Pathology;

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Anja Sandholm· 2 shared David FurmaniD· 2 shared Duncan Croll· 2 shared Fiona SenchynaiD· 2 shared Hideto DeguchiiD· 2 shared Judith CampisiiD· 2 shared Jun‐Wei B. HughesiD· 2 shared Lisa EllerbyiD· 2 shared

Activity by Year

2021-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCell Biology

Anja Sandholm

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Uncovering senescent fibroblast heterogeneity connects DNA damage response to idiopathic pulmonary fibrosis

Jun‐Wei B. Hughes, Akshay Pujari, Anja Sandholm, Duncan Croll, Lea B. Monk, Isaac Joshua, Rachel Butterfield, Corrigan Horton, Kevin Schneider, Fiona Senchyna, Ian Brown, Zhixin A. Zhang, T. Ho, Tsung-Che Ho, Hideto Deguchi, , Judith Campisi

The paper identifies senescent fibroblast heterogeneity in IPF and links it to DNA damage response dysregulation using gene expression analysis.

npj Aging · Jun 18, 2026Peer-reviewedCell Biology

In vitro comparison of Aβ-targeting SNIPR, synNotch, and TRUCK for cell-based drug delivery in Alzheimer's disease.

Cynthia J. Siebrand, Zachary Mayeri, Ian Brown, Julie Kay Andersen, Chaska C. Walton

The paper compares SNIPR, synNotch, and TRUCK systems for Aβ-targeting cell-based drug delivery in Alzheimer's disease, finding SNIPR and synNotch outperform TRUCK in therapeutic response.

bioRxiv · May 4, 2026 · PreprintNeuroscience

DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons

Jun‐Wei B. Hughes, Anja Sandholm, Duncan Croll, Fiona Senchyna, Kevin Schneider, Rachel Butterfield, Tyne L.M. McHugh, Ian Brown, Hideto Deguchi, Tyler A. U. Hilsabeck, Sally K. Mak, Kenneth A. Wilson, Hayk Davtyan, Mathew M. Blurton-Jones, Joseph R. Herdy, , Judith Campisi

This study shows DNA damage in neurons leads to a senescent-like state similar to Alzheimer's disease, with distinct features from fibroblasts.

bioRxiv · Apr 3, 2026 · PreprintCell Biology

DNA damage alters nuclear mechanics through chromatin reorganisation.

Alia dos Santos, Alexander W Cook, Rosemarie E Gough, Martin Martin Schilling, Nora Aleida Olszok, Ian Brown, Lin Wang, Jesse Arron, Marisa Luisa Martin-Fernandez, Florian Rehfeldt, Christopher P Toseland

This study investigates how DNA damage affects nuclear mechanics through chromatin reorganisation, finding reduced nuclear stiffness and increased chromatin decondensation that may enhance DNA repair.

Nucleic Acids Research · Jan 11, 2021Peer-reviewedBiophysics