T. Ho

Uncovering senescent fibroblast heterogeneity connects DNA damage response to idiopathic pulmonary fibrosis

The paper identifies senescent fibroblast heterogeneity in IPF and links it to DNA damage response dysregulation using gene expression analysis.

The renal capsule, a vibrant and adaptive cell environment of the kidney in homeostasis and aging

This study characterizes the renal capsule's cellular composition and dynamics in health, aging, and disease, revealing its adaptive responses and age-related changes.

A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice

The paper demonstrates a glycolytic metabolon on the plasma membrane that directly controls KATP channels in pancreatic α and β cells from humans and mice through ATP/ADP and NAD+/NADH cycles.

Site-specific Halogenation of Peptides and Proteins using engineered Halogenase Enzymes

The paper demonstrates in vitro halogenation of peptides using engineered halogenase enzymes and identifies a preferred substrate motif.

The isoforms of pyruvate kinase act as nutrient sensors for the β-cell KATP channel

This study identifies PKm1 and PKm2 as nutrient sensors that regulate β-cell KATP channels through mitochondrial PEP, influencing insulin secretion and Ca2+ oscillations.

Dataset on the mass spectrometry-based proteomic profiling of mouse embryonic fibroblasts from a wild type and DYT-TOR1A mouse model of dystonia, basally and during stress

The paper presents subcellular proteomic data from wildtype and DYT-TOR1A mouse embryonic fibroblasts under basal and stress conditions to study TorsinA's role in dystonia.

Characterization of endogenous Rubus yellow net virus in raspberries

This study characterizes endogenous Rubus yellow net virus (endoRYNV) in raspberries, revealing diverse endoRYNV sequences and their prevalence due to limited germplasm use in breeding programs.

Genetic Disruption of WASHC4 Drives Endo-lysosomal Dysfunction and Cognitive-Movement Impairments in Mice and Humans

This study identifies a mutation in WASHC4 causing endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans.

SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation

This study identifies SLC45A2's role in melanosome pH regulation and pigmentation, showing its function in melanin synthesis and how a variant affects protein stability and pigmentation.

Both DNA binding domains of p53 are required for its ultra rapid recruitment to sites of UV damage

The paper shows p53 requires both DNA binding and C-terminal domains for ultra-rapid recruitment to UV damage sites, which is PARP-dependent and inhibited by cancer-associated mutations.

Pyruvate kinase controls signal strength in the insulin secretory pathway

This paper shows pyruvate kinase (PK) controls insulin secretion by regulating ATP/ADP ratios and mitochondrial metabolism in beta-cells, suggesting PK activation as a potential diabetes therapy.