MicrobiologybioRxivPreprint
Characterization of Tigurilysin, a Novel Human CD59-Specific Cholesterol-Dependent Cytolysin, Reveals a Role for Host Specificity in Augmenting Toxin Activity
Ifrah Shahi, Sophia A. Dongas, Juliana K. Ilmain…·Adam J. Ratner
This study characterizes tigurilysin, a novel hCD59-specific CDC, showing it requires both hCD59 and cholesterol for activity and exhibits increased lysis efficiency due to host specificity.
DOI 10.1101/2023.06.21.545930