Molecular BiologyNucleic Acids ResearchPeer-reviewed
Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity, and cellular functions
Idir Malki, Inara Liepina, Nora Kogelnik…·Cyril Dominguez
This study identifies Cdk1-mediated phosphorylation of Sam68 at T33 and T317, showing it reduces RNA binding and alternative splicing activity, promoting cell proliferation and inhibiting apoptosis in HCT116 cells.
21 citations