NeuroscienceeLifePeer-reviewed
Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model
Núria Martín‐Flores, Marina Podpolny, Faye McLeod…·Patricia C. Salinas
This study shows that DKK3, a Wnt antagonist elevated in Alzheimer's disease, causes synaptic loss and memory impairment, but its knockdown restores synapse integrity and memory in a mouse model.
15 citations